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Preheat Oven to 350°F.
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In a large mixing bowl, combine the egg, bread crumbs, onion, salt and pepper.
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Add the ground beef to the mixture and mix well. Press half of the beef mixture into the bottom of a greased loaf pan. Sprinkle 3/4 cup of the pepper jack cheese over meat to within 1/2 inch of sides. Press remaining beef mixture over cheese.
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Bake uncovered for 50-55 minutes or until the meat is no longer pink. Sprinkle the remaining cheese over meatloaf and bake an additional 5 minutes until cheese is melted.
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Let meatloaf stand for 10 minutes before slicing. Serve with salsa if desired.